A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4(+) T cells

The transcription factor ThPOK promotes CD4(+) T cell differentiation in the thymus. Here, using a mouse strain that allows post-thymic gene deletion, we show that ThPOK maintains CD4(+) T lineage integrity and couples effector differentiation to environmental cues after antigenic stimulation. ThPOK...

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Detalles Bibliográficos
Autores principales: Vacchio, Melanie S., Wang, Lie, Bouladoux, Nicolas, Carpenter, Andrea C., Xiong, Yumei, Williams, Linus C., Wohlfert, Elizabeth, Song, Ki-Duk, Belkaid, Yasmine, Love, Paul E., Bosselut, Rémy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251968/
https://www.ncbi.nlm.nih.gov/pubmed/25129370
http://dx.doi.org/10.1038/ni.2960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251968/
https://www.ncbi.nlm.nih.gov/pubmed/25129370
http://dx.doi.org/10.1038/ni.2960

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