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Osteoblasts from osteoarthritis patients show enhanced susceptibility to Ross River virus infection associated with delayed type I interferon responses

BACKGROUND: Arthritogenic alphaviruses such as Ross River virus (RRV) and chikungunya virus (CHIKV) have caused widespread outbreaks of chronic polyarthritis. The inflammatory responses in alphavirus-induced arthritis and osteoarthritis (OA) share many similar features, which suggests the possibilit...

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Detalles Bibliográficos
Autores principales: Chen, Weiqiang, Foo, Suan-Sin, Li, Rachel W, Smith, Paul N, Mahalingam, Suresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252017/
https://www.ncbi.nlm.nih.gov/pubmed/25407789
http://dx.doi.org/10.1186/s12985-014-0189-9