Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86

BACKGROUND: The RET tyrosine kinase receptor has emerged as a target in thyroid and endocrine resistant breast cancer. We previously reported the synthesis of kinase inhibitors with potent activity against RET. Herein, we have further investigated the effect of the lead compound SPP86 on RET mediate...

Descripción completa

Detalles Bibliográficos
Autores principales: Alao, John P, Michlikova, Sona, Dinér, Peter, Grøtli, Morten, Sunnerhagen, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252022/
https://www.ncbi.nlm.nih.gov/pubmed/25409876
http://dx.doi.org/10.1186/1471-2407-14-853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252022/
https://www.ncbi.nlm.nih.gov/pubmed/25409876
http://dx.doi.org/10.1186/1471-2407-14-853

Ejemplares similares