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Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86
BACKGROUND: The RET tyrosine kinase receptor has emerged as a target in thyroid and endocrine resistant breast cancer. We previously reported the synthesis of kinase inhibitors with potent activity against RET. Herein, we have further investigated the effect of the lead compound SPP86 on RET mediate...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252022/ https://www.ncbi.nlm.nih.gov/pubmed/25409876 http://dx.doi.org/10.1186/1471-2407-14-853 |