A Semi-Physiologically Based Pharmacokinetic Pharmacodynamic Model for Glycyrrhizin-Induced Pseudoaldosteronism and Prediction of the Dose Limit Causing Hypokalemia in a Virtual Elderly Population

Glycyrrhizin (GL) is a widely used food additive which can cause severe pseudoaldosteronism at high doses or after a long period of consumption. The aim of the present study was to develop a physiologically based pharmacokinetic (PBPK) pharmacodynamic (PD) model for GL-induced pseudoaldosteronism to...

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Detalles Bibliográficos
Autores principales: Xu, Ruijuan, Liu, Xiaoquan, Yang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252094/
https://www.ncbi.nlm.nih.gov/pubmed/25463381
http://dx.doi.org/10.1371/journal.pone.0114049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252094/
https://www.ncbi.nlm.nih.gov/pubmed/25463381
http://dx.doi.org/10.1371/journal.pone.0114049

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