HER2 confers drug resistance of human breast cancer cells through activation of NRF2 by direct interaction

Overexpression and/or activation of HER2 confers resistance of cancer cells to chemotherapeutic drugs. NRF2 also gives drug resistance of cancer cells through induction of detoxification and/or drug efflux proteins. Although several upstream effectors of NRF2 overlapped with the downstream molecules...

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Detalles Bibliográficos
Autores principales: Kang, Hyo Jin, Yi, Yong Weon, Hong, Young Bin, Kim, Hee Jeong, Jang, Young-Joo, Seong, Yeon-Sun, Bae, Insoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252900/
https://www.ncbi.nlm.nih.gov/pubmed/25467193
http://dx.doi.org/10.1038/srep07201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252900/
https://www.ncbi.nlm.nih.gov/pubmed/25467193
http://dx.doi.org/10.1038/srep07201

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