Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo

Deposition of amyloid β protein (Aβ) to form neuritic plaques in the brain is the pathological hallmark of Alzheimer's disease (AD). Aβ is produced by β- and γ-cleavages of amyloid β precursor protein (APP). Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a de-ubiquitinating enzyme that cle...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Mingming, Cai, Fang, Zhang, Shuting, Zhang, Si, Song, Weihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252905/
https://www.ncbi.nlm.nih.gov/pubmed/25466238
http://dx.doi.org/10.1038/srep07298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252905/
https://www.ncbi.nlm.nih.gov/pubmed/25466238
http://dx.doi.org/10.1038/srep07298

Ejemplares similares