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Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo

Deposition of amyloid β protein (Aβ) to form neuritic plaques in the brain is the pathological hallmark of Alzheimer's disease (AD). Aβ is produced by β- and γ-cleavages of amyloid β precursor protein (APP). Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a de-ubiquitinating enzyme that cle...

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Detalles Bibliográficos
Autores principales:	Zhang, Mingming, Cai, Fang, Zhang, Shuting, Zhang, Si, Song, Weihong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252905/ https://www.ncbi.nlm.nih.gov/pubmed/25466238 http://dx.doi.org/10.1038/srep07298

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