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Positive allosteric modulation of the adenosine A(2a) receptor attenuates inflammation
BACKGROUND: Adenosine is produced at high levels at inflamed sites as a by-product of cellular activation and breakdown. Adenosine mediates its anti-inflammatory activity primarily through the adenosine A(2a) receptor (A(2a)R), a member of the G-protein coupled receptors. A(2a)R agonists have demons...
Autores principales: | Welihinda, Ajith A, Amento, Edward P |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253011/ https://www.ncbi.nlm.nih.gov/pubmed/25473378 http://dx.doi.org/10.1186/s12950-014-0037-0 |
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