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Evaluation of acid-labile S-protecting groups to prevent Cys racemization in Fmoc solid-phase peptide synthesis

Phosphonium and uronium salt-based reagents enable efficient and effective coupling reactions and are indispensable in peptide chemistry, especially in machine-assisted SPPS. However, after the activating and coupling steps with these reagents in the presence of tertiary amines, Fmoc derivatives of...

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Detalles Bibliográficos
Autores principales:	Hibino, Hajime, Miki, Yasuyoshi, Nishiuchi, Yuji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253322/ https://www.ncbi.nlm.nih.gov/pubmed/24357151 http://dx.doi.org/10.1002/psc.2585

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