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Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo

Neutral competition, an emerging feature of stem cell homeostasis, posits that individual stem cells can be lost and replaced by their neighbors stochastically, resulting in chance dominance of a clone at the niche. A single stem cell with an oncogenic mutation could bias this process and clonally s...

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Detalles Bibliográficos
Autores principales: Amoyel, Marc, Simons, Benjamin D, Bach, Erika A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253521/
https://www.ncbi.nlm.nih.gov/pubmed/25092766
http://dx.doi.org/10.15252/embj.201387500