Haplotype defined by the MLH1-93G/A polymorphism is associated with MLH1 promoter hypermethylation in sporadic colorectal cancers

BACKGROUND: Methylation of the MLH1 promoter region has been suggested to be a major mechanism of gene inactivation in sporadic microsatellite instability-positive (MSI-H) colorectal cancers (CRCs). Recently, single-nucleotide polymorphism (SNP) in the MLH1 promoter region (MLH1-93G/A; rs1800734) ha...

Descripción completa

Detalles Bibliográficos
Autores principales: Miyakura, Yasuyuki, Tahara, Makiko, Lefor, Alan T, Yasuda, Yoshikazu, Sugano, Kokichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253604/
https://www.ncbi.nlm.nih.gov/pubmed/25421847
http://dx.doi.org/10.1186/1756-0500-7-835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253604/
https://www.ncbi.nlm.nih.gov/pubmed/25421847
http://dx.doi.org/10.1186/1756-0500-7-835

Ejemplares similares