PDGF-AA Promotes Osteogenic Differentiation and Migration of Mesenchymal Stem Cell by Down-Regulating PDGFRα and Derepressing BMP-Smad1/5/8 Signaling

Platelet-derived growth factors (PDGFs) play important roles in skeletal development and bone fracture healing, yet how PDGFs execute their functions remains incompletely understood. Here we show that PDGF-AA, but not -AB or -BB, could activate the BMP-Smad1/5/8 pathway in mesenchymal stem cells (MS...

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Detalles Bibliográficos
Autores principales: Li, Anna, Xia, Xuechun, Yeh, James, Kua, Huiyi, Liu, Huijuan, Mishina, Yuji, Hao, Aijun, Li, Baojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254917/
https://www.ncbi.nlm.nih.gov/pubmed/25470749
http://dx.doi.org/10.1371/journal.pone.0113785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254917/
https://www.ncbi.nlm.nih.gov/pubmed/25470749
http://dx.doi.org/10.1371/journal.pone.0113785

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