Antiviral Interferon-Beta Signaling Induced by Designed Transcription Activator-Like Effectors (TALE)

Here we show that designed transcription activator-like effectors (TALEs) that bind to defined areas of the interferon beta promoter are capable to induce IFN-beta expression and signaling in human cells. Importantly, TALE-mediated IFN-beta signaling occurs independently of pathogen pattern recognit...

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Detalles Bibliográficos
Autores principales: Renner, Ivonne, Funk, Nancy, Geissler, Rene, Friedrich, Susann, Penzel, Anika, Behrens, Sven-Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255017/
https://www.ncbi.nlm.nih.gov/pubmed/25470486
http://dx.doi.org/10.1371/journal.pone.0114288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255017/
https://www.ncbi.nlm.nih.gov/pubmed/25470486
http://dx.doi.org/10.1371/journal.pone.0114288

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