Antiviral Interferon-Beta Signaling Induced by Designed Transcription Activator-Like Effectors (TALE)

Here we show that designed transcription activator-like effectors (TALEs) that bind to defined areas of the interferon beta promoter are capable to induce IFN-beta expression and signaling in human cells. Importantly, TALE-mediated IFN-beta signaling occurs independently of pathogen pattern recognit...

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Detalles Bibliográficos
Autores principales: Renner, Ivonne, Funk, Nancy, Geissler, Rene, Friedrich, Susann, Penzel, Anika, Behrens, Sven-Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255017/
https://www.ncbi.nlm.nih.gov/pubmed/25470486
http://dx.doi.org/10.1371/journal.pone.0114288
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author Renner, Ivonne
Funk, Nancy
Geissler, Rene
Friedrich, Susann
Penzel, Anika
Behrens, Sven-Erik
author_facet Renner, Ivonne
Funk, Nancy
Geissler, Rene
Friedrich, Susann
Penzel, Anika
Behrens, Sven-Erik
author_sort Renner, Ivonne
collection PubMed
description Here we show that designed transcription activator-like effectors (TALEs) that bind to defined areas of the interferon beta promoter are capable to induce IFN-beta expression and signaling in human cells. Importantly, TALE-mediated IFN-beta signaling occurs independently of pathogen pattern recognition but effectively prohibits viral RNA replication as demonstrated with a hepatitis C virus replicon. TALEs were thus indicated to be valuable tools in various applications addressing, for example, virus-host interactions.
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spelling pubmed-42550172014-12-11 Antiviral Interferon-Beta Signaling Induced by Designed Transcription Activator-Like Effectors (TALE) Renner, Ivonne Funk, Nancy Geissler, Rene Friedrich, Susann Penzel, Anika Behrens, Sven-Erik PLoS One Research Article Here we show that designed transcription activator-like effectors (TALEs) that bind to defined areas of the interferon beta promoter are capable to induce IFN-beta expression and signaling in human cells. Importantly, TALE-mediated IFN-beta signaling occurs independently of pathogen pattern recognition but effectively prohibits viral RNA replication as demonstrated with a hepatitis C virus replicon. TALEs were thus indicated to be valuable tools in various applications addressing, for example, virus-host interactions. Public Library of Science 2014-12-03 /pmc/articles/PMC4255017/ /pubmed/25470486 http://dx.doi.org/10.1371/journal.pone.0114288 Text en © 2014 Renner et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Renner, Ivonne
Funk, Nancy
Geissler, Rene
Friedrich, Susann
Penzel, Anika
Behrens, Sven-Erik
Antiviral Interferon-Beta Signaling Induced by Designed Transcription Activator-Like Effectors (TALE)
title Antiviral Interferon-Beta Signaling Induced by Designed Transcription Activator-Like Effectors (TALE)
title_full Antiviral Interferon-Beta Signaling Induced by Designed Transcription Activator-Like Effectors (TALE)
title_fullStr Antiviral Interferon-Beta Signaling Induced by Designed Transcription Activator-Like Effectors (TALE)
title_full_unstemmed Antiviral Interferon-Beta Signaling Induced by Designed Transcription Activator-Like Effectors (TALE)
title_short Antiviral Interferon-Beta Signaling Induced by Designed Transcription Activator-Like Effectors (TALE)
title_sort antiviral interferon-beta signaling induced by designed transcription activator-like effectors (tale)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255017/
https://www.ncbi.nlm.nih.gov/pubmed/25470486
http://dx.doi.org/10.1371/journal.pone.0114288
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