Relationship between therapeutic efficacy of doxorubicin-transferrin conjugate and expression of P-glycoprotein in chronic erythromyeloblastoid leukemia cells sensitive and resistant to doxorubicin

BACKGROUND: Conjugation of anti-neoplastic agents with human proteins is a strategy to diminish the toxic side effects of anthracycline antibiotics. We have developed a novel doxorubicin-transferrin (DOX-TRF) conjugate aimed to direct anticancer drugs against therapeutic targets that display altered...

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Detalles Bibliográficos
Autores principales: Szwed, Marzena, Kania, Katarzyna D., Jozwiak, Zofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255090/
https://www.ncbi.nlm.nih.gov/pubmed/25410120
http://dx.doi.org/10.1007/s13402-014-0205-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255090/
https://www.ncbi.nlm.nih.gov/pubmed/25410120
http://dx.doi.org/10.1007/s13402-014-0205-5

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