Pro: Are we ready to translate Alzheimer's disease modifying therapies to people with Down syndrome?

BACKGROUND: Down Syndrome (DS) is caused by trisomy of chromosome 21, which includes the gene for the amyloid precursor protein (APP) and leads to overproduction of beta-amyloid. Clinical-pathological studies indicate that individuals with DS begin demonstrating Alzheimer’s disease (AD) pathology du...

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Detalles Bibliográficos
Autor principal: Rafii, Michael S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Debate
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255529/
https://www.ncbi.nlm.nih.gov/pubmed/25478025
http://dx.doi.org/10.1186/s13195-014-0060-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255529/
https://www.ncbi.nlm.nih.gov/pubmed/25478025
http://dx.doi.org/10.1186/s13195-014-0060-7

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