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Pro: Are we ready to translate Alzheimer's disease modifying therapies to people with Down syndrome?
BACKGROUND: Down Syndrome (DS) is caused by trisomy of chromosome 21, which includes the gene for the amyloid precursor protein (APP) and leads to overproduction of beta-amyloid. Clinical-pathological studies indicate that individuals with DS begin demonstrating Alzheimer’s disease (AD) pathology du...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255529/ https://www.ncbi.nlm.nih.gov/pubmed/25478025 http://dx.doi.org/10.1186/s13195-014-0060-7 |