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The secretion of von Willebrand factor from endothelial cells; an increasingly complicated story

von Willebrand factor (VWF) plays key roles in both primary and secondary hemostasis by capturing platelets and chaperoning clotting factor VIII, respectively. It is stored within the Weibel–Palade bodies (WPBs) of endothelial cells as a highly prothrombotic protein, and its release is thus necessar...

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Detalles Bibliográficos
Autores principales: Nightingale, T, Cutler, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255685/
https://www.ncbi.nlm.nih.gov/pubmed/23809123
http://dx.doi.org/10.1111/jth.12225