Role of distinct surfaces of the G9a ankyrin repeat domain in histone and DNA methylation during embryonic stem cell self-renewal and differentiation

BACKGROUND: Epigenetic modifications such as histone and DNA methylation are essential for silencing pluripotency genes during embryonic stem cell (ESC) differentiation. G9a is the major histone H3 Lys9 (H3K9) methyltransferase in euchromatin and is required for the de novo DNA methylation of the ke...

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Detalles Bibliográficos
Autores principales: Bittencourt, Danielle, Lee, Brian H, Gao, Lu, Gerke, Daniel S, Stallcup, Michael R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255711/
https://www.ncbi.nlm.nih.gov/pubmed/25478012
http://dx.doi.org/10.1186/1756-8935-7-27

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255711/
https://www.ncbi.nlm.nih.gov/pubmed/25478012
http://dx.doi.org/10.1186/1756-8935-7-27

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