1,4-Disubstituted-[1,2,3]triazolyl-Containing Analogues of MT-II: Design, Synthesis, Conformational Analysis, and Biological Activity

[Image: see text] Side chain-to-side chain cyclizations represent a strategy to select a family of bioactive conformations by reducing the entropy and enhancing the stabilization of functional ligand-induced receptor conformations. This structural manipulation contributes to increased target specifi...

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Detalles Bibliográficos
Autores principales: Testa, Chiara, Scrima, Mario, Grimaldi, Manuela, D’Ursi, Anna M., Dirain, Marvin L., Lubin-Germain, Nadège, Singh, Anamika, Haskell-Luevano, Carrie, Chorev, Michael, Rovero, Paolo, Papini, Anna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255721/
https://www.ncbi.nlm.nih.gov/pubmed/25347033
http://dx.doi.org/10.1021/jm501027w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255721/
https://www.ncbi.nlm.nih.gov/pubmed/25347033
http://dx.doi.org/10.1021/jm501027w

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