Fragment-Based Screening of the Bromodomain of ATAD2

[Image: see text] Cellular and genetic evidence suggest that inhibition of ATAD2 could be a useful strategy to treat several types of cancer. To discover small-molecule inhibitors of the bromodomain of ATAD2, we used a fragment-based approach. Fragment hits were identified using NMR spectroscopy, an...

Descripción completa

Detalles Bibliográficos
Autores principales: Harner, Mary J., Chauder, Brian A., Phan, Jason, Fesik, Stephen W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255743/
https://www.ncbi.nlm.nih.gov/pubmed/25314628
http://dx.doi.org/10.1021/jm501035j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255743/
https://www.ncbi.nlm.nih.gov/pubmed/25314628
http://dx.doi.org/10.1021/jm501035j

Ejemplares similares