Total Synthesis of (±)-Paroxetine by Diastereoconvergent Cobalt-Catalysed Arylation

A total synthesis of paroxetine is reported, with a diastereoselective and diastereoconvergent cobalt-catalysed sp(3)–sp(2) coupling reaction involving a 3-substituted 4-bromo-N-Boc-piperidine (Boc = tert-butoxycarbonyl) substrate as a key step. A 9:1 diastereoselectivity was obtained, while a contr...

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Detalles Bibliográficos
Autores principales: Despiau, Carole F, Dominey, Andrew P, Harrowven, David C, Linclau, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255755/
https://www.ncbi.nlm.nih.gov/pubmed/25505371
http://dx.doi.org/10.1002/ejoc.201402108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255755/
https://www.ncbi.nlm.nih.gov/pubmed/25505371
http://dx.doi.org/10.1002/ejoc.201402108

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