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Total Synthesis of (±)-Paroxetine by Diastereoconvergent Cobalt-Catalysed Arylation
A total synthesis of paroxetine is reported, with a diastereoselective and diastereoconvergent cobalt-catalysed sp(3)–sp(2) coupling reaction involving a 3-substituted 4-bromo-N-Boc-piperidine (Boc = tert-butoxycarbonyl) substrate as a key step. A 9:1 diastereoselectivity was obtained, while a contr...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
WILEY-VCH Verlag
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255755/ https://www.ncbi.nlm.nih.gov/pubmed/25505371 http://dx.doi.org/10.1002/ejoc.201402108 |