Empty virions in AAV8 vector preparations reduce transduction efficiency and may cause total viral particle dose-limiting side effects

Empty virions are inadvertent by-products of recombinant adeno-associated virus (rAAV) packaging process, resulting in vector lots with mixtures of full and empty virions at variable ratios. Impact of empty virions on the efficiency and side effects of rAAV transduction has not been well characteriz...

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Detalles Bibliográficos
Autores principales: Gao, Kai, Li, Mengxin, Zhong, Li, Su, Qin, Li, Jia, Li, Shaoyong, He, Ran, Zhang, Yu, Hendricks, Gregory, Wang, Junzhi, Gao, Guangping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255953/
https://www.ncbi.nlm.nih.gov/pubmed/25485285
http://dx.doi.org/10.1038/mtm.2013.9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255953/
https://www.ncbi.nlm.nih.gov/pubmed/25485285
http://dx.doi.org/10.1038/mtm.2013.9

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