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Molecular Dynamics Study of the Opening Mechanism for DNA Polymerase I
During DNA replication, DNA polymerases follow an induced fit mechanism in order to rapidly distinguish between correct and incorrect dNTP substrates. The dynamics of this process are crucial to the overall effectiveness of catalysis. Although X-ray crystal structures of DNA polymerase I with substr...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256020/ https://www.ncbi.nlm.nih.gov/pubmed/25474643 http://dx.doi.org/10.1371/journal.pcbi.1003961 |