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Molecular Dynamics Study of the Opening Mechanism for DNA Polymerase I

During DNA replication, DNA polymerases follow an induced fit mechanism in order to rapidly distinguish between correct and incorrect dNTP substrates. The dynamics of this process are crucial to the overall effectiveness of catalysis. Although X-ray crystal structures of DNA polymerase I with substr...

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Detalles Bibliográficos
Autores principales:	Miller, Bill R., Parish, Carol A., Wu, Eugene Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256020/ https://www.ncbi.nlm.nih.gov/pubmed/25474643 http://dx.doi.org/10.1371/journal.pcbi.1003961

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