Direct analysis of mAb aggregates in mammalian cell culture supernatant

BACKGROUND: Protein aggregation during monoclonal antibody (mAb) production can occur in upstream and downstream processing (DSP). Current methods to determine aggregate formation during cell culture include size exclusion chromatography (SEC) with a previous affinity chromatography step in order to...

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Detalles Bibliográficos
Autores principales: Paul, Albert J, Schwab, Karen, Hesse, Friedemann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256052/
https://www.ncbi.nlm.nih.gov/pubmed/25431119
http://dx.doi.org/10.1186/s12896-014-0099-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256052/
https://www.ncbi.nlm.nih.gov/pubmed/25431119
http://dx.doi.org/10.1186/s12896-014-0099-3

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