Exploring O(2) Diffusion in A-Type Cytochrome c Oxidases: Molecular Dynamics Simulations Uncover Two Alternative Channels towards the Binuclear Site

Cytochrome c oxidases (Ccoxs) are the terminal enzymes of the respiratory chain in mitochondria and most bacteria. These enzymes couple dioxygen (O(2)) reduction to the generation of a transmembrane electrochemical proton gradient. Despite decades of research and the availability of a large amount o...

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Detalles Bibliográficos
Autores principales: Oliveira, A. Sofia F., Damas, João M., Baptista, António M., Soares, Cláudio M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256069/
https://www.ncbi.nlm.nih.gov/pubmed/25474152
http://dx.doi.org/10.1371/journal.pcbi.1004010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256069/
https://www.ncbi.nlm.nih.gov/pubmed/25474152
http://dx.doi.org/10.1371/journal.pcbi.1004010

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