A Systematic Computational Analysis of Biosynthetic Gene Cluster Evolution: Lessons for Engineering Biosynthesis

Bacterial secondary metabolites are widely used as antibiotics, anticancer drugs, insecticides and food additives. Attempts to engineer their biosynthetic gene clusters (BGCs) to produce unnatural metabolites with improved properties are often frustrated by the unpredictability and complexity of the...

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Detalles Bibliográficos
Autores principales: Medema, Marnix H., Cimermancic, Peter, Sali, Andrej, Takano, Eriko, Fischbach, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256081/
https://www.ncbi.nlm.nih.gov/pubmed/25474254
http://dx.doi.org/10.1371/journal.pcbi.1004016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256081/
https://www.ncbi.nlm.nih.gov/pubmed/25474254
http://dx.doi.org/10.1371/journal.pcbi.1004016

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