The Tau Tubulin Kinases TTBK1/2 Promote Accumulation of Pathological TDP-43

Pathological aggregates of phosphorylated TDP-43 characterize amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP), two devastating groups of neurodegenerative disease. Kinase hyperactivity may be a consistent feature of ALS and FTLD-TDP, as phosphorylated TDP-43 is n...

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Detalles Bibliográficos
Autores principales: Liachko, Nicole F., McMillan, Pamela J., Strovas, Timothy J., Loomis, Elaine, Greenup, Lynne, Murrell, Jill R., Ghetti, Bernardino, Raskind, Murray A., Montine, Thomas J., Bird, Thomas D., Leverenz, James B., Kraemer, Brian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256087/
https://www.ncbi.nlm.nih.gov/pubmed/25473830
http://dx.doi.org/10.1371/journal.pgen.1004803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256087/
https://www.ncbi.nlm.nih.gov/pubmed/25473830
http://dx.doi.org/10.1371/journal.pgen.1004803

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