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Topoisomerase I Plays a Critical Role in Suppressing Genome Instability at a Highly Transcribed G-Quadruplex-Forming Sequence

G-quadruplex or G4 DNA is a non-B secondary DNA structure that comprises a stacked array of guanine-quartets. Cellular processes such as transcription and replication can be hindered by unresolved DNA secondary structures potentially endangering genome maintenance. As G4-forming sequences are highly...

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Detalles Bibliográficos
Autores principales:	Yadav, Puja, Harcy, Victoria, Argueso, Juan Lucas, Dominska, Margaret, Jinks-Robertson, Sue, Kim, Nayun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256205/ https://www.ncbi.nlm.nih.gov/pubmed/25473964 http://dx.doi.org/10.1371/journal.pgen.1004839

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