Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering

The kinase PINK1 and the E3 ubiquitin (Ub) ligase Parkin participate in mitochondrial quality control. The phosphorylation of Ser65 in Parkin's ubiquitin-like (UBl) domain by PINK1 stimulates Parkin activation and translocation to damaged mitochondria, which induces mitophagy generating polyUb...

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Detalles Bibliográficos
Autores principales: Shiba-Fukushima, Kahori, Arano, Taku, Matsumoto, Gen, Inoshita, Tsuyoshi, Yoshida, Shigeharu, Ishihama, Yasushi, Ryu, Kwon-Yul, Nukina, Nobuyuki, Hattori, Nobutaka, Imai, Yuzuru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256268/
https://www.ncbi.nlm.nih.gov/pubmed/25474007
http://dx.doi.org/10.1371/journal.pgen.1004861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256268/
https://www.ncbi.nlm.nih.gov/pubmed/25474007
http://dx.doi.org/10.1371/journal.pgen.1004861

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