Increased and Imbalanced dNTP Pools Symmetrically Promote Both Leading and Lagging Strand Replication Infidelity

The fidelity of DNA replication requires an appropriate balance of dNTPs, yet the nascent leading and lagging strands of the nuclear genome are primarily synthesized by replicases that differ in subunit composition, protein partnerships and biochemical properties, including fidelity. These facts pos...

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Detalles Bibliográficos
Autores principales: Buckland, Robert J., Watt, Danielle L., Chittoor, Balasubramanyam, Nilsson, Anna Karin, Kunkel, Thomas A., Chabes, Andrei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256292/
https://www.ncbi.nlm.nih.gov/pubmed/25474551
http://dx.doi.org/10.1371/journal.pgen.1004846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256292/
https://www.ncbi.nlm.nih.gov/pubmed/25474551
http://dx.doi.org/10.1371/journal.pgen.1004846

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