Cargando…

SHP2 Positively Regulates TGFβ1-induced Epithelial-Mesenchymal Transition Modulated by Its Novel Interacting Protein Hook1

The epithelial-mesenchymal transition (EMT) is an essential process for embryogenesis. It also plays a critical role in the initiation of tumor metastasis. Src homology 2 (SH2)-domain containing protein-tyrosine phosphatase-2 (SHP2) is a ubiquitously expressed protein-tyrosine phosphatase and is mut...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Shuomin, Wang, Linrun, Zhao, Qingwei, Liu, Yu, He, Lingjuan, Xu, Qinqin, Sun, Xu, Teng, Li, Cheng, Hongqiang, Ke, Yuehai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256348/ https://www.ncbi.nlm.nih.gov/pubmed/25331952 http://dx.doi.org/10.1074/jbc.M113.546077

Ejemplares similares

The prognostic significance of SHP2 and its binding protein Hook1 in non-small cell lung cancer
por: He, Lingjuan, et al.
Publicado: (2019)

PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer
por: Avasarala, Sreedevi, et al.
Publicado: (2015)

Counteracting Effects Operating on Src Homology 2 Domain-containing Protein-tyrosine Phosphatase 2 (SHP2) Function Drive Selection of the Recurrent Y62D and Y63C Substitutions in Noonan Syndrome
por: Martinelli, Simone, et al.
Publicado: (2012)

The Chromatin Assembly Factor Complex 1 (CAF1) and 5-Azacytidine (5-AzaC) Affect Cell Motility in Src-transformed Human Epithelial Cells
por: Endo, Akinori, et al.
Publicado: (2017)

Epigenetic Silencing of β-Spectrin, a TGF-β Signaling/Scaffolding Protein in a Human Cancer Stem Cell Disorder: BECKWITH-WIEDEMANN SYNDROME
por: Yao, Zhi-Xing, et al.
Publicado: (2010)

The Orphan Nuclear Receptor NR4A1 Protects Pancreatic β-Cells from Endoplasmic Reticulum (ER) Stress-mediated Apoptosis
por: Yu, Cong, et al.
Publicado: (2015)

MAGI-1 Interacts with Nephrin to Maintain Slit Diaphragm Structure through Enhanced Rap1 Activation in Podocytes
por: Ni, Jie, et al.
Publicado: (2016)

Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1
por: Li, Li, et al.
Publicado: (2017)

Up-regulation of the kinase gene SGK1 by progesterone activates the AP-1–NDRG1 axis in both PR-positive and -negative breast cancer cells
por: Godbole, Mukul, et al.
Publicado: (2018)

High Mobility Group Box-1 (HMGB1) Participates in the Pathogenesis of Alcoholic Liver Disease (ALD)
por: Ge, Xiaodong, et al.
Publicado: (2014)

Calpain activation mediates microgravity-induced myocardial abnormalities in mice via p38 and ERK1/2 MAPK pathways
por: Liang, Liwen, et al.
Publicado: (2021)

Stromal Hyaluronan Interaction with Epithelial CD44 Variants Promotes Prostate Cancer Invasiveness by Augmenting Expression and Function of Hepatocyte Growth Factor and Androgen Receptor
por: Ghatak, Shibnath, et al.
Publicado: (2010)

Novel Role for γ-Catenin in the Regulation of Cancer Cell Migration via the Induction of Hepatocyte Growth Factor Activator Inhibitor Type 1 (HAI-1)
por: Sechler, Marybeth, et al.
Publicado: (2015)

Talin1 Has Unique Expression versus Talin 2 in the Heart and Modifies the Hypertrophic Response to Pressure Overload
por: Manso, Ana Maria, et al.
Publicado: (2013)

Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice
por: Michailidou, Zoi, et al.
Publicado: (2012)

Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells
por: Vilema-Enríquez, Gabriela, et al.
Publicado: (2021)

Understanding the Interactions between the Proteins Implicated in Legius Syndrome and Neurofibromatosis Type 1(♦): Interaction between a Domain of the Negative Regulator of the Ras-ERK Pathway, SPRED1 Protein, and the GTPase-activating Protein-related Domain of Neurofibromin Is Implicated in Legius Syndrome and Neurofibromatosis Type 1
Publicado: (2016)

The Coronary Artery Disease-associated Coding Variant in Zinc Finger C3HC-type Containing 1 (ZC3HC1) Affects Cell Cycle Regulation
por: Jones, Peter D., et al.
Publicado: (2016)

Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity
por: Horiuchi, Takahiro, et al.
Publicado: (2017)

Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologies
por: Lautenschläger, Janin, et al.
Publicado: (2020)

Therapeutic targeting of pancreatic cancer stem cells by dexamethasone modulation of the MKP-1–JNK axis
por: Suzuki, Shuhei, et al.
Publicado: (2021)

Cyclin F/FBXO1 Interacts with HIV-1 Viral Infectivity Factor (Vif) and Restricts Progeny Virion Infectivity by Ubiquitination and Proteasomal Degradation of Vif Protein through SCF(cyclin F) E3 Ligase Machinery
por: Augustine, Tracy, et al.
Publicado: (2017)

Glutathione S-Transferase Omega 1 Activity Is Sufficient to Suppress Neurodegeneration in a Drosophila Model of Parkinson Disease
por: Kim, Kiyoung, et al.
Publicado: (2012)

Nephrocystin-4 Regulates Pyk2-induced Tyrosine Phosphorylation of Nephrocystin-1 to Control Targeting to Monocilia
por: Liebau, Max C., et al.
Publicado: (2011)

The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 via pyrimidine depletion
por: Dembitz, Vilma, et al.
Publicado: (2019)

Effects of deficiency in the RLBP1-encoded visual cycle protein CRALBP on visual dysfunction in humans and mice
por: Lima de Carvalho, Jose Ronaldo, et al.
Publicado: (2020)

Molecular Architecture of a Complex between an Adhesion Protein from the Malaria Parasite and Intracellular Adhesion Molecule 1
por: Brown, Alan, et al.
Publicado: (2013)

NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction
por: Juhasz, Agnes, et al.
Publicado: (2017)

An aberrantly sustained emergency granulopoiesis response accelerates postchemotherapy relapse in MLL1-rearranged acute myeloid leukemia in mice
por: Wang, Hao, et al.
Publicado: (2020)

The serine protease HtrA1 cleaves misfolded transforming growth factor β–induced protein (TGFBIp) and induces amyloid formation
por: Poulsen, Ebbe Toftgaard, et al.
Publicado: (2019)

Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites
por: Yan, Yan, et al.
Publicado: (2017)

Disruption of the ATP-binding Cassette B7 (ABTM-1/ABCB7) Induces Oxidative Stress and Premature Cell Death in Caenorhabditis elegans
por: González-Cabo, Pilar, et al.
Publicado: (2011)

Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression
por: Tatler, Amanda L., et al.
Publicado: (2016)

A Novel Kleefstra Syndrome-associated Variant That Affects the Conserved TPLX Motif within the Ankyrin Repeat of EHMT1 Leads to Abnormal Protein Folding
por: Blackburn, Patrick R., et al.
Publicado: (2017)

The Legs at odd angles (Loa) Mutation in Cytoplasmic Dynein Ameliorates Mitochondrial Function in SOD1(G93A) Mouse Model for Motor Neuron Disease
por: El-Kadi, Ali Morsi, et al.
Publicado: (2010)

Characterization of a stable HIV-1 B/C recombinant, soluble, and trimeric envelope glycoprotein (Env) highly resistant to CD4-induced conformational changes
por: Kumar, Rajesh, et al.
Publicado: (2017)

Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology
por: Michno, Wojciech, et al.
Publicado: (2019)

Inhibition of p38 Mitogen-activated Protein Kinase Impairs Influenza Virus-induced Primary and Secondary Host Gene Responses and Protects Mice from Lethal H5N1 Infection
por: Börgeling, Yvonne, et al.
Publicado: (2014)

Knock-in rats with homozygous PSEN1(L435F) Alzheimer mutation are viable and show selective γ-secretase activity loss causing low Aβ40/42 and high Aβ43
por: Tambini, Marc D., et al.
Publicado: (2020)

Transient β(2)-Adrenoceptor Activation Confers Pregnancy Loss by Disrupting Embryo Spacing at Implantation
por: Chen, Qi, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_7rrmq5ubqvk5hfg4karev2t8o1