Structure-Function Analyses of Human Kallikrein-related Peptidase 2 Establish the 99-Loop as Master Regulator of Activity

Human kallikrein-related peptidase 2 (KLK2) is a tryptic serine protease predominantly expressed in prostatic tissue and secreted into prostatic fluid, a major component of seminal fluid. Most likely it activates and complements chymotryptic KLK3 (prostate-specific antigen) in cleaving seminal clott...

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Detalles Bibliográficos
Autores principales: Skala, Wolfgang, Utzschneider, Daniel T., Magdolen, Viktor, Debela, Mekdes, Craik, Charles S., Brandstetter, Hans, Goettig, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256358/
https://www.ncbi.nlm.nih.gov/pubmed/25326387
http://dx.doi.org/10.1074/jbc.M114.598201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256358/
https://www.ncbi.nlm.nih.gov/pubmed/25326387
http://dx.doi.org/10.1074/jbc.M114.598201

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