AS101 Prevents Diabetic Nephropathy Progression and Mesangial Cell Dysfunction: Regulation of the AKT Downstream Pathway

Diabetic nephropathy (DN) is characterized by proliferation of mesangial cells, mesangial expansion, hypertrophy and extracellular matrix accumulation. Previous data have cross-linked PKB (AKT) to TGFβ induced matrix modulation. The non-toxic compound AS101 has been previously shown to favorably aff...

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Detalles Bibliográficos
Autores principales: Shemesh, Itay Israel, Rozen-Zvi, Benaya, Kalechman, Yona, Gafter, Uzi, Sredni, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256394/
https://www.ncbi.nlm.nih.gov/pubmed/25474550
http://dx.doi.org/10.1371/journal.pone.0114287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256394/
https://www.ncbi.nlm.nih.gov/pubmed/25474550
http://dx.doi.org/10.1371/journal.pone.0114287

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