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AS101 Prevents Diabetic Nephropathy Progression and Mesangial Cell Dysfunction: Regulation of the AKT Downstream Pathway
Diabetic nephropathy (DN) is characterized by proliferation of mesangial cells, mesangial expansion, hypertrophy and extracellular matrix accumulation. Previous data have cross-linked PKB (AKT) to TGFβ induced matrix modulation. The non-toxic compound AS101 has been previously shown to favorably aff...
Autores principales: | Shemesh, Itay Israel, Rozen-Zvi, Benaya, Kalechman, Yona, Gafter, Uzi, Sredni, Benjamin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256394/ https://www.ncbi.nlm.nih.gov/pubmed/25474550 http://dx.doi.org/10.1371/journal.pone.0114287 |
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