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Monoacylglycerol Lipase Inhibitor JZL184 Improves Behavior and Neural Properties in Ts65Dn Mice, a Model of Down Syndrome
Genetic alterations or pharmacological treatments affecting endocannabinoid signaling have profound effects on synaptic and neuronal properties and, under certain conditions, may improve higher brain functions. Down syndrome (DS), a developmental disorder caused by triplication of chromosome 21, is...
Autores principales: | Lysenko, Larisa V., Kim, Jeesun, Henry, Cassandra, Tyrtyshnaia, Anna, Kohnz, Rebecca A., Madamba, Francisco, Simon, Gabriel M., Kleschevnikova, Natalia E., Nomura, Daniel K., Ezekowitz, R . Alan B., Kleschevnikov, Alexander M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256450/ https://www.ncbi.nlm.nih.gov/pubmed/25474204 http://dx.doi.org/10.1371/journal.pone.0114521 |
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