SV40 Utilizes ATM Kinase Activity to Prevent Non-homologous End Joining of Broken Viral DNA Replication Products

Simian virus 40 (SV40) and cellular DNA replication rely on host ATM and ATR DNA damage signaling kinases to facilitate DNA repair and elicit cell cycle arrest following DNA damage. During SV40 DNA replication, ATM kinase activity prevents concatemerization of the viral genome whereas ATR activity p...

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Detalles Bibliográficos
Autores principales: Sowd, Gregory A., Mody, Dviti, Eggold, Joshua, Cortez, David, Friedman, Katherine L., Fanning, Ellen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256475/
https://www.ncbi.nlm.nih.gov/pubmed/25474690
http://dx.doi.org/10.1371/journal.ppat.1004536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256475/
https://www.ncbi.nlm.nih.gov/pubmed/25474690
http://dx.doi.org/10.1371/journal.ppat.1004536

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