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Deficiency of the bone mineralization inhibitor NPP1 protects mice against obesity and diabetes
The emergence of bone as an endocrine regulator has prompted a re-evaluation of the role of bone mineralization factors in the development of metabolic disease. Ectonucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) controls bone mineralization through the generation of pyrophosphate, and levels...
Autores principales: | Huesa, Carmen, Zhu, Dongxing, Glover, James D., Ferron, Mathieu, Karsenty, Gerard, Milne, Elspeth M., Millan, José Luis, Ahmed, S. Faisal, Farquharson, Colin, Morton, Nicholas M., MacRae, Vicky E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Limited
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257003/ https://www.ncbi.nlm.nih.gov/pubmed/25368121 http://dx.doi.org/10.1242/dmm.017905 |
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