Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo

Mutations in LRRK2 cause a dominantly inherited form of Parkinson’s disease (PD) and are the most common known genetic determinant of PD. Inhibitor-based therapies targeting LRRK2 have emerged as a key therapeutic strategy in PD; thus, understanding the consequences of inhibiting the normal cellular...

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Detalles Bibliográficos
Autores principales: Dodson, Mark W., Leung, Lok K., Lone, Mohiddin, Lizzio, Michael A., Guo, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257004/
https://www.ncbi.nlm.nih.gov/pubmed/25288684
http://dx.doi.org/10.1242/dmm.017020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257004/
https://www.ncbi.nlm.nih.gov/pubmed/25288684
http://dx.doi.org/10.1242/dmm.017020

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