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Injectable long-acting systems for Radix Ophiopogonis polysaccharide based on mono-PEGylation and in situ formation of a PLGA depot

BACKGROUND: Radix Ophiopogonis polysaccharide (ROP), a highly hydrophilic macromolecule, has a unique anti-ischemic action in the myocardium. One of the main problems with its use is its relatively short half-life in vivo. To solve this problem, injectable long-acting drug delivery systems, which co...

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Detalles Bibliográficos
Autores principales:	Shi, XiaoLi, Lin, Xiao, Zheng, XiangWei, Feng, Yi, Shen, Lan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257019/ https://www.ncbi.nlm.nih.gov/pubmed/25489243 http://dx.doi.org/10.2147/IJN.S71819

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