Anti-CTGF Single-Chain Variable Fragment Dimers Inhibit Human Airway Smooth Muscle (ASM) Cell Proliferation by Down-Regulating p-Akt and p-mTOR Levels

Connective tissue growth factor (CTGF) contributes to airway smooth muscle (ASM) cell hyperplasia in asthma. Humanized single-chain variable fragment antibody (scFv) was well characterized as a CTGF antagonist in the differentiation of fibroblast into myofibroblast and pulmonary fibrosis in our prev...

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Detalles Bibliográficos
Autores principales: Gao, Wei, Cai, Liting, Xu, Xudong, Fan, Juxiang, Xue, Xiulei, Yan, Xuejiao, Qu, Qinrong, Wang, Xihua, Zhang, Chen, Wu, Guoqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257608/
https://www.ncbi.nlm.nih.gov/pubmed/25478966
http://dx.doi.org/10.1371/journal.pone.0113980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257608/
https://www.ncbi.nlm.nih.gov/pubmed/25478966
http://dx.doi.org/10.1371/journal.pone.0113980

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