Cargando…

Structures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control

Plasmodium parasites, the causative agent of malaria, rely heavily on de novo folate biosynthesis, and the enzymes in this pathway have therefore been explored extensively for antimalarial development. Serine hydroxymethyltransferase (SHMT) from Plasmodium spp., an enzyme involved in folate recyclin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chitnumsub, Penchit, Jaruwat, Aritsara, Riangrungroj, Pinpunya, Ittarat, Wanwipa, Noytanom, Krittikar, Oonanant, Worrapoj, Vanichthanankul, Jarunee, Chuankhayan, Phimonphan, Maenpuen, Somchart, Chen, Chun-Jung, Chaiyen, Pimchai, Yuthavong, Yongyuth, Leartsakulpanich, Ubolsree
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2014
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257618/ https://www.ncbi.nlm.nih.gov/pubmed/25478836 http://dx.doi.org/10.1107/S1399004714023128

Ejemplares similares

The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities
por: Chitnumsub, Penchit, et al.
Publicado: (2014)

Plasmodium serine hydroxymethyltransferase as a potential anti-malarial target: inhibition studies using improved methods for enzyme production and assay
por: Sopitthummakhun, Kittipat, et al.
Publicado: (2012)

Structural insights into a flavin-dependent dehalogenase HadA explain catalysis and substrate inhibition via quadruple π-stacking
por: Pimviriyakul, Panu, et al.
Publicado: (2021)

Catalytic and structural insights into a stereospecific and thermostable Class II aldolase HpaI from Acinetobacter baumannii
por: Watthaisong, Pratchaya, et al.
Publicado: (2021)

Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase gene
por: Tirakarn, Srisuda, et al.
Publicado: (2012)

Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization
por: Pornthanakasem, Wichai, et al.
Publicado: (2012)

Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance
por: Tarnchompoo, Bongkoch, et al.
Publicado: (2018)

Dissecting the low catalytic capability of flavin-dependent halogenases
por: Phintha, Aisaraphon, et al.
Publicado: (2020)

In Silico and In Vitro Potential of FDA-Approved Drugs for Antimalarial Drug Repurposing against Plasmodium Serine Hydroxymethyltransferases
por: Mee-udorn, Pitchayathida, et al.
Publicado: (2023)

C22 podovirus infectivity is associated with intermediate stiffness
por: Sae-Ueng, Udom, et al.
Publicado: (2020)

Thermoresponsive C22 phage stiffness modulates the phage infectivity
por: Sae-Ueng, Udom, et al.
Publicado: (2022)

3,4-Dihydroxyphenylacetate 2,3-dioxygenase from Pseudomonas aeruginosa: An Fe(II)-containing enzyme with fast turnover
por: Pornsuwan, Soraya, et al.
Publicado: (2017)

Diaminoquinazoline MMV675968 from Pathogen Box inhibits Acinetobacter baumannii growth through targeting of dihydrofolate reductase
por: Songsungthong, Warangkhana, et al.
Publicado: (2019)

BeQuIK (Biosensor Engineered Quorum Induced Killing): designer bacteria for destroying recalcitrant biofilms
por: Riangrungroj, Pinpunya, et al.
Publicado: (2019)

Avian influenza A/H5N1 neuraminidase expressed in yeast with a functional head domain
por: Yongkiettrakul, S., et al.
Publicado: (2009)

Discovery of new non-pyrimidine scaffolds as Plasmodium falciparum DHFR inhibitors by fragment-based screening
por: Hoarau, Marie, et al.
Publicado: (2021)

Whole genome sequence of pan drug-resistant clinical isolate of Acinetobacter baumannii ST1890
por: Wongsuk, Thanwa, et al.
Publicado: (2022)

Characterization of Virulence Factors in Candida Species Causing Candidemia in a Tertiary Care Hospital in Bangkok, Thailand
por: Saiprom, Natnaree, et al.
Publicado: (2023)

A label-free optical whole-cell Escherichia coli biosensor for the detection of pyrethroid insecticide exposure
por: Riangrungroj, Pinpunya, et al.
Publicado: (2019)

Preface
por: Chaiyen, Pimchai, et al.
Publicado: (2020)

Unifying and versatile features of flavin-dependent monooxygenases: Diverse catalysis by a common C4a-(hydro)peroxyflavin
por: Phintha, Aisaraphon, et al.
Publicado: (2023)

Oxidative dehalogenation and denitration by a flavin-dependent monooxygenase is controlled by substrate deprotonation
por: Pimviriyakul, Panu, et al.
Publicado: (2018)

Rapid kinetics reveal surprising flavin chemistry in bifurcating electron transfer flavoprotein from Acidaminococcus fermentans
por: Sucharitakul, Jeerus, et al.
Publicado: (2020)

Crystal structure and catalytic mechanism of the essential m(1)G37 tRNA methyltransferase TrmD from Pseudomonas aeruginosa
por: Jaroensuk, Juthamas, et al.
Publicado: (2019)

Microbial degradation of halogenated aromatics: molecular mechanisms and enzymatic reactions
por: Pimviriyakul, Panu, et al.
Publicado: (2019)

High sensitivity and low-cost flavin luciferase (FLUX(Vc))-based reporter gene for mammalian cell expression
por: Phonbuppha, Jittima, et al.
Publicado: (2023)

Application of WST-8 based colorimetric NAD(P)H detection for quantitative dehydrogenase assays
por: Chamchoy, Kamonwan, et al.
Publicado: (2019)

An in vivo selection system with tightly regulated gene expression enables directed evolution of highly efficient enzymes
por: Nearmnala, Parinthon, et al.
Publicado: (2021)

Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model
por: Tipsuwan, Wachiraporn, et al.
Publicado: (2011)

Structural and functional insight into serine hydroxymethyltransferase from Helicobacter pylori
por: Sodolescu, Andreea, et al.
Publicado: (2018)

Determinants of Thermostability in Serine Hydroxymethyltransferase Identified by Principal Component Analysis
por: Leng, Fei, et al.
Publicado: (2017)

Induction of serine hydroxymethyltransferase 2 promotes tumorigenesis and metastasis in neuroblastoma
por: Clark, Rachael A., et al.
Publicado: (2022)

Molecular Docking Studies, Synthesis and Biological Evaluation of Substituted Pyrimidine‐2,4‐diamines as Inhibitors of Plasmodium falciparum Dihydrofolate Reductase
por: Somandi, Khonzisizwe, et al.
Publicado: (2022)

Expression of a secretory α-glucosidase II from Apis cerana indica in Pichia pastoris and its characterization
por: Kaewmuangmoon, Jirattikarn, et al.
Publicado: (2013)

Functional analysis of BPSS2242 reveals its detoxification role in Burkholderia pseudomallei under salt stress
por: Chamchoy, Kamonwan, et al.
Publicado: (2020)

A novel bicyclic 2,4-diaminopyrimidine inhibitor of Streptococcus suis dihydrofolate reductase
por: Songsungthong, Warangkhana, et al.
Publicado: (2021)

Magnetic field effects as a result of the radical pair mechanism are unlikely in redox enzymes
por: Messiha, Hanan L., et al.
Publicado: (2015)

An electrochemical method for detecting the biomarker 4-HPA by allosteric activation of Acinetobacterbaumannii reductase C1 subunit
por: Teanphonkrang, Somjai, et al.
Publicado: (2021)

Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening
por: Somsak, Voravuth, et al.
Publicado: (2011)

Chloroplastic Serine Hydroxymethyltransferase From Medicago truncatula: A Structural Characterization
por: Ruszkowski, Milosz, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_fu1m591u70r75749amsttq334l