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IL-6 Stimulates Intestinal Epithelial Proliferation and Repair after Injury
IL-6 is a pleiotropic cytokine often associated with inflammation. Inhibition of this pathway has led to successful treatment of rheumatoid arthritis, but one unforeseen potential complication of anti-IL-6 therapy is bowel perforation. Within the intestine, IL-6 has been shown to prevent epithelial...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257684/ https://www.ncbi.nlm.nih.gov/pubmed/25478789 http://dx.doi.org/10.1371/journal.pone.0114195 |
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author | Kuhn, Kristine A. Manieri, Nicholas A. Liu, Ta-Chiang Stappenbeck, Thaddeus S. |
author_facet | Kuhn, Kristine A. Manieri, Nicholas A. Liu, Ta-Chiang Stappenbeck, Thaddeus S. |
author_sort | Kuhn, Kristine A. |
collection | PubMed |
description | IL-6 is a pleiotropic cytokine often associated with inflammation. Inhibition of this pathway has led to successful treatment of rheumatoid arthritis, but one unforeseen potential complication of anti-IL-6 therapy is bowel perforation. Within the intestine, IL-6 has been shown to prevent epithelial apoptosis during prolonged inflammation. The role of IL-6 in the intestine during an initial inflammatory insult is unknown. Here, we evaluate the role of IL-6 at the onset of an inflammatory injury. Using two murine models of bowel injury – wound by biopsy and bacterial triggered colitis – we demonstrated that IL-6 is induced soon after injury by multiple cell types including intraepithelial lymphocytes. Inhibition of IL-6 resulted in impaired wound healing due to decreased epithelial proliferation. Using intestinal tissue obtained from patients who underwent surgical resection of the colon due to traumatic perforation, we observed cells with detectable IL-6 within the area of perforation and not at distant sites. Our data demonstrate the important role of IL-6 produced in part by intraepithelial lymphocytes at the onset of an inflammatory injury for epithelial proliferation and wound repair. |
format | Online Article Text |
id | pubmed-4257684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-42576842014-12-15 IL-6 Stimulates Intestinal Epithelial Proliferation and Repair after Injury Kuhn, Kristine A. Manieri, Nicholas A. Liu, Ta-Chiang Stappenbeck, Thaddeus S. PLoS One Research Article IL-6 is a pleiotropic cytokine often associated with inflammation. Inhibition of this pathway has led to successful treatment of rheumatoid arthritis, but one unforeseen potential complication of anti-IL-6 therapy is bowel perforation. Within the intestine, IL-6 has been shown to prevent epithelial apoptosis during prolonged inflammation. The role of IL-6 in the intestine during an initial inflammatory insult is unknown. Here, we evaluate the role of IL-6 at the onset of an inflammatory injury. Using two murine models of bowel injury – wound by biopsy and bacterial triggered colitis – we demonstrated that IL-6 is induced soon after injury by multiple cell types including intraepithelial lymphocytes. Inhibition of IL-6 resulted in impaired wound healing due to decreased epithelial proliferation. Using intestinal tissue obtained from patients who underwent surgical resection of the colon due to traumatic perforation, we observed cells with detectable IL-6 within the area of perforation and not at distant sites. Our data demonstrate the important role of IL-6 produced in part by intraepithelial lymphocytes at the onset of an inflammatory injury for epithelial proliferation and wound repair. Public Library of Science 2014-12-05 /pmc/articles/PMC4257684/ /pubmed/25478789 http://dx.doi.org/10.1371/journal.pone.0114195 Text en © 2014 Kuhn et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Kuhn, Kristine A. Manieri, Nicholas A. Liu, Ta-Chiang Stappenbeck, Thaddeus S. IL-6 Stimulates Intestinal Epithelial Proliferation and Repair after Injury |
title | IL-6 Stimulates Intestinal Epithelial Proliferation and Repair after Injury |
title_full | IL-6 Stimulates Intestinal Epithelial Proliferation and Repair after Injury |
title_fullStr | IL-6 Stimulates Intestinal Epithelial Proliferation and Repair after Injury |
title_full_unstemmed | IL-6 Stimulates Intestinal Epithelial Proliferation and Repair after Injury |
title_short | IL-6 Stimulates Intestinal Epithelial Proliferation and Repair after Injury |
title_sort | il-6 stimulates intestinal epithelial proliferation and repair after injury |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257684/ https://www.ncbi.nlm.nih.gov/pubmed/25478789 http://dx.doi.org/10.1371/journal.pone.0114195 |
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