Immunomodulation of human intestinal T cells by the synthetic CD80 antagonist RhuDex®

Deregulated activation of mucosal lamina propria T cells plays a central role in the pathogenesis of intestinal inflammation. One of the means to attenuate T cell activation is by blocking the CD28/CD80 co-stimulatory pathway. Here we investigate RhuDex®, a small molecule that binds to human CD80, f...

Descripción completa

Detalles Bibliográficos
Autores principales: Heninger, Anne-Kristin, Wentrup, Sabine, Al-Saeedi, Mohammed, Schiessling, Serin, Giese, Thomas, Wartha, Florian, Meuer, Stefan, Schröder-Braunstein, Jutta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257762/
https://www.ncbi.nlm.nih.gov/pubmed/25505551
http://dx.doi.org/10.1002/iid3.34

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257762/
https://www.ncbi.nlm.nih.gov/pubmed/25505551
http://dx.doi.org/10.1002/iid3.34

Ejemplares similares