Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy

Astrocytes are an attractive cell target for gene therapy but the validation of new therapeutic candidates is needed. We determined whether adeno-associated viral (AAV) vector-mediated overexpression of glutamine synthetase (GS) or excitatory amino acid transporter 2 (EAAT2), or expression of microR...

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Detalles Bibliográficos
Autores principales: Young, Deborah, Fong, Dahna M., Lawlor, Patricia A., Wu, Angela, Mouravlev, Alexandre, McRae, Michelle, Glass, Michelle, Dragunow, Michael, During, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257851/
https://www.ncbi.nlm.nih.gov/pubmed/25231174
http://dx.doi.org/10.1038/gt.2014.82

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257851/
https://www.ncbi.nlm.nih.gov/pubmed/25231174
http://dx.doi.org/10.1038/gt.2014.82

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