A Tool Set to Map Allosteric Networks through the NMR Chemical Shift Covariance Analysis

Allostery is an essential regulatory mechanism of biological function. Allosteric sites are also pharmacologically relevant as they are often targeted with higher selectivity than orthosteric sites. However, a comprehensive map of allosteric sites poses experimental challenges because allostery is d...

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Detalles Bibliográficos
Autores principales: Boulton, Stephen, Akimoto, Madoka, Selvaratnam, Rajeevan, Bashiri, Amir, Melacini, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258684/
https://www.ncbi.nlm.nih.gov/pubmed/25482377
http://dx.doi.org/10.1038/srep07306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258684/
https://www.ncbi.nlm.nih.gov/pubmed/25482377
http://dx.doi.org/10.1038/srep07306

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