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A Tool Set to Map Allosteric Networks through the NMR Chemical Shift Covariance Analysis
Allostery is an essential regulatory mechanism of biological function. Allosteric sites are also pharmacologically relevant as they are often targeted with higher selectivity than orthosteric sites. However, a comprehensive map of allosteric sites poses experimental challenges because allostery is d...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258684/ https://www.ncbi.nlm.nih.gov/pubmed/25482377 http://dx.doi.org/10.1038/srep07306 |